If you drive a lot in your motor home repairs are almost certainly a necessity at some time. Of course, the usual safety tips are required if you are taking a long journey: check the brakes, the lights, the oil levels, the radiator, etc. Also, check the tires for adequate tire pressure, make sure your spare tire is ready, just in case.
When driving in difficult weather (like snow, rain, or such like) you may have to use additional checks, drive slower and exercise caution at all times. You can’t just barrel down the road as you might normally.